Dr. Wael Sabra

Biotechnology

Faculty of Life Sciences

Research Associate

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+49 2821 80673 9661

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Kleve Campus

Marie-Curie-Straße 1, 47533 Kleve

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Contact in Faculty of Life Sciences

Location

Kleve Campus

Marie-Curie-Straße 1, 47533 Kleve

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Sabra, W., Villotti, S., Fensterle, J., Zeng, A.-P., & Haddad, A. M. (2026). Metabolic Flux and Growth Profiling of Megasphaera cerevisiae for Medium-Chain Fatty Acid Synthesis. Environmental microbiology reports, 18(4), e70390. https://doi.org/10.1111/1758-2229.70390.
Al-Agamy, M. H., Kelany, M. S., Alshehri, S., Alhuzani, M. R., Hamed, M. M., Sabra, W., & Mahdi, W. A. (2025). Multifaceted Applications of Synthesized Silver Nanoparticles From Marine Fungus Aspergillus flavus MK4: Antimicrobial, Anticancer, and Wound-Healing Properties. BioMed Research International, 2025(1), 7161915. https://doi.org/10.1155/bmri/7161915.
Sabra, W., Wang, W., Goepfert, C., & Zeng, A.-P. (2022). Food web and metabolic interactions of the lung inhabitants Streptococcus pneumoniae and Pseudomonas aeruginosa. Environmental Microbiology, 24(10), 4885–4898. https://doi.org/10.1111/1462-2920.16105.
Arbter, P., Sabra, W., Utesch, T., Hong, Y., & Zeng, A.-P. (2021). Metabolomic and kinetic investigations on the electricity‐aided production of butanol by Clostridium pasteurianum strains. Engineering in Life Sciences, 21(3-4), 181–195. https://doi.org/10.1002/elsc.202000035.
Selder, L., Sabra, W., Wang, W., Prescher, C., & Zeng, A.-P. (2021). 5 Bioconversion and downstream processing in the context of biorefinery: Principles and process examples. In M. Aresta, A. Dibenedetto, & F. Dumeignil (editors), Biorefinery: From Biomass to Chemicals and Fuels – Towards Circular Economy (2., überarbeitete Auflage, pp. 123–164). De Gruyter. https://doi.org/10.1515/9783110705386-006.
El-Helow, E. R., Atalla, R. G., Sabra, W., & Lotfy, W. A. (2020). Kinetic studies on the expression of alginate and extracellular proteins by Pseudomonas aeruginosa FRD1 and PAO1. The Journal of General and Applied Microbiology, 66(1), 15–23. https://doi.org/10.2323/jgam.2019.04.003.
Selder, L., Sabra, W., Jürgensen, N., Lakshmanan, A., & Zeng, A.-P. (2020). Co-cultures with integrated in situ product removal for lactate-based propionic acid production. Bioprocess and Biosystems Engineering, 43(6), 1027–1035. https://doi.org/10.1007/s00449-020-02300-0.
Utesch, T., Sabra, W., Prescher, C., Baur, J., Arbter, P., & Zeng, A.-P. (2019). Enhanced electron transfer of different mediators for strictly opposite shifting of metabolism in Clostridium pasteurianum grown on glycerol in a new electrochemical bioreactor. Biotechnology and Bioengineering, 116(7), 1627–1643. https://doi.org/10.1002/bit.26963.
Lotfy, W. A., Atalla, R. G., Sabra, W., & El-Helow, E. R. (2018). Expression of extracellular polysaccharides and proteins by clinical isolates of Pseudomonas aeruginosa in response to environmental conditions. International Microbiology, 21(3), 129–142. https://doi.org/10.1007/s10123-018-0010-5.
Schmitz, R., Sabra, W., Arbter, P., Hong, Y., Utesch, T., & Zeng, A.-P. (2018). Improved electrocompetence and metabolic engineering of Clostridium pasteurianum reveals a new regulation pattern of glycerol fermentation. Engineering in Life Sciences, 19(6), 412–422. https://doi.org/10.1002/elsc.201800118.
Groeger, C., Wang, W., Sabra, W., Utesch, T., & Zeng, A.-P. (2017). Metabolic and proteomic analyses of product selectivity and redox regulation in Clostridium pasteurianum grown on glycerol under varied iron availability. Microbial Cell Factories, 16(), 64. https://doi.org/10.1186/s12934-017-0678-9.
Sabra, W., Bommareddy, R. R., Maheshwari, G., Papanikolaou, S., & Zeng, A.-P. (2017). Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: insights through transcriptome and fluxome analyses. Microbial Cell Factories, 16(1), 1–14. https://doi.org/10.1186/s12934-017-0690-0.
Bommareddy, R. R., Sabra, W., & Zeng, A.-P. (2016). Glucose‐mediated regulation of glycerol uptake in Rhodosporidium toruloides: Insights through transcriptomic analysis on dual substrate fermentation. Engineering in Life Sciences, 17(3), 282–291. https://doi.org/10.1002/elsc.201600010.
Groeger, C., Sabra, W., & Zeng, A.-P. (2016). Simultaneous production of 1,3‐propanediol and n‐butanol by Clostridium pasteurianum: In situ gas stripping and cellular metabolism. Engineering in Life Sciences, 16(7), 664–674. https://doi.org/10.1002/elsc.201600058.
Sabra, W., Wang, W., Surandram, S., Groeger, C., & Zeng, A.-P. (2016). Fermentation of mixed substrates by Clostridium pasteurianum and its physiological, metabolic and proteomic characterizations. Microbial Cell Factories, 15(1), 129–142. https://doi.org/10.1186/s12934-016-0497-4.
Bommareddy, R. R., Sabra, W., Maheshwari, G., & Zeng, A.-P. (2015). Metabolic network analysis and experimental study of lipid production in Rhodosporidium toruloides grown on single and mixed substrates. Microbial Cell Factories, 14(), 1–13. https://doi.org/10.1186/s12934-015-0217-5.
Groeger, C., Sabra, W., & Zeng, A.-P. (2015). 4. Introduction to bioconversion and downstream processing: principles and process examples (pp. 81–108). De Gruyter. https://doi.org/10.1515/9783110331585-008.
Sabra, W., Röske, I., Sahm, K., Antranikian, G., & Zeng, A.-P. (2015). High temperature biogas reactors to treat stillage from an industrial bioethanol process: Metabolic and microbial characterization. Engineering in Life Sciences, 15(7), 743–750. https://doi.org/10.1002/elsc.201500040.
Sabra, W., Groeger, C., & Zeng, A.-P. (2015). Microbial Cell Factories for Diol Production. In Q. Ye, J. Bao, & J.-J. Zhong (editors), Bioreactor Engineering Research and Industrial Applications I (pp. 165–197). Springer. https://doi.org/10.1007/10_2015_330.
Groeger, C., Sabra, W., & Zeng, A.-P. (2014). Co‐Produktion von 1,3‐Propandiol und n‐Butanol mit Clostridium pasteurianum und In‐situ‐Butanolabtrennung. Chemie Ingenieur Technik, 86(9), 1490. https://doi.org/10.1002/cite.201450164.
Röske, I., Sabra, W., Nacke, H., Daniel, R., Zeng, A.-P., Antranikian, G., & Sahm, K. (2014). Microbial community composition and dynamics in high-temperature biogas reactors using industrial bioethanol waste as substrate. Applied Microbiology and Biotechnology, 98(21), 9095–9106. https://doi.org/10.1007/s00253-014-5906-1.
Sabra, W., Groeger, C., Sharma, P., & Zeng, A.-P. (2014). Improved n-butanol production by a non-acetone producing Clostridium pasteurianum DSMZ 525 in mixed substrate fermentation. Applied Microbiology and Biotechnology, 98(9), 4267–4276. https://doi.org/10.1007/s00253-014-5588-8.
Sabra, W. (2014). Mixed Microbial Cultures for Industrial Biotechnology: Success, Chance and Challenges. In P. Grunwald (editor), Industrial Biocatalysis (pp. 205–237). Jenny Stanford Publishing. https://doi.org/10.1201/b17828-9.
Dietz, D., Sabra, W., & Zeng, A.-P. (2013). Co-cultivation of Lactobacillus zeae and Veillonella criceti for the production of propionic acid. AMB Express, 3(), 1–9. https://doi.org/10.1186/2191-0855-3-29.
Rappert, S., Song, L., Sabra, W., Wang, W., & Zeng, A.-P. (2013). Draft Genome Sequence of Type Strain Clostridium pasteurianum DSM 525 (ATCC 6013), a Promising Producer of Chemicals and Fuels. Genome Announcements, 1(1), e00232–12. https://doi.org/10.1128/genomea.00232-12.
Sabra, W., Dietz, D., & Zeng, A.-P. (2013). Substrate-limited co-culture for efficient production of propionic acid from flour hydrolysate. Applied Microbiology and Biotechnology, 97(13), 5771–5777. https://doi.org/10.1007/s00253-013-4913-y.
Sabra, W., Haddad, A. M., & Zeng, A.-P. (2013). Comparative physiological study of the wild type and the small colony variant of Pseudomonas aeruginosa 20265 under controlled growth conditions. World Journal of Microbiology and Biotechnology, 30(3), 1027–1036. https://doi.org/10.1007/s11274-013-1521-z.
Sabra, W., Quitmann, H., Zeng, A.-P., Dai, J.-Y., & Xiu, Z. (2011). Microbial Production of 2,3-Butanediol. In M. Moo-Young (editor), Comprehensive Biotechnology (2 ed., pp. 87–97). ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. https://doi.org/10.1016/b978-0-08-088504-9.00161-6.
Zeng, A.-P., & Sabra, W. (2011). Microbial production of diols as platform chemicals: Recent progresses. Current Opinion in Biotechnology, 22(6), 749–757. https://doi.org/10.1016/j.copbio.2011.05.005.
Sabra, W., Dietz, D., Tjahjasari, D., & Zeng, A.-P. (2010). Biosystems analysis and engineering of microbial consortia for industrial biotechnology. Engineering in Life Sciences, 10(5), 407–421. https://doi.org/10.1002/elsc.201000111.
Sabra, W., & Zeng, A. (2009). Microbial Production of Alginates: Physiology and Process Aspects. In B. H. A. Rehm (editor), Alginates: Biology and Applications (pp. 153–173). SPRINGER HEIDELBERG. https://doi.org/10.1007/978-3-540-92679-5_7.
Sabra, W., Tawfik, A. F., & Shibl, A. M. (2009). Evaluation of a new method for antifungal susceptibility testing for azoles. World Journal of Microbiology and Biotechnology, 26(3), 451–457. https://doi.org/10.1007/s11274-009-0188-y.
Sabra, W. A., & Abou-Zeid, D.-M. (2008). Improving Feeding Strategies for Maximizing Polyhdroxybutyrate Yield by Bacillus megaterium. Research Journal of Microbiology, 3(5), 308–318. https://doi.org/10.3923/jm.2008.308.318.
Sabra, W., & Hassan, M. (2008). Exopolysaccharide Yield as a Kinetic Parameter for the Statistical Optimization of EPS Production by Klebsiella pneumoniae. Biotechnology(Faisalabad), 7(1), 27–34. https://doi.org/10.3923/biotech.2008.27.34.
Kim, E.-J., Sabra, W., & Zeng, A.-P. (2003). Iron deficiency leads to inhibition of oxygen transfer and enhanced formation of virulence factors in cultures of Pseudomonas aeruginosa PAO1. Microbiology, 149(9), 2627–2634. https://doi.org/10.1099/mic.0.26276-0.
Sabra, W., Lünsdorf, H., & Zeng, A.-P. (2003). Alterations in the formation of lipopolysaccharide and membrane vesicles on the surface of Pseudomonas aeruginosa PAO1 under oxygen stress conditions. Microbiology, 149(10), 2789–2795. https://doi.org/10.1099/mic.0.26443-0.
Sabra, W., Ma, H., Wang, W., Kim, E.-J., & Zeng, A.-C. (2002). Rekonstruktion und Analyse des metabolischen Netzwerks vonPseudomonas aeruginosa für die Bildung von Virulenzfaktoren. In Chemie Ingenieur Technik (Vol. 74, Issue 5, pp. 688). https://doi.org/10.1002/1522-2640(200205)74:5<688::aid-cite688>3.0.co;2-4.
Sabra, W., Kim, E.-J., & Zeng, A.-P. (2002). Physiological responses of Pseudomonas aeruginosa PAO1 to oxidative stress in controlled microaerobic and aerobic cultures. Microbiology, 148(10), 3195–3202. https://doi.org/10.1099/00221287-148-10-3195.
Bi, J., Wirth, M., Beer, C., Sabra, W., & Zeng, A.-P. (2001). The Use of a C-FOS-GFP Reporter System for Monitoring Apoptosis of Animal Cells Induced by Exotoxins of Pseudomonas Aeruginosa. In Animal Cell Technology: From Target to Market (pp. 79–82). SPRINGER. https://doi.org/10.1007/978-94-010-0369-8_18.
Sabra, W., Zeng, A.-P., & Deckwer, W.-D. (2001). Bacterial alginate: physiology, product quality and process aspects. Applied Microbiology and Biotechnology, 56(3-4), 315–325. https://doi.org/10.1007/s002530100699.
Sabra, W., Zeng, A.-P., Lünsdorf, H., & Deckwer, W.-D. (2000). Effect of Oxygen on Formation and Structure of Azotobacter vinelandii Alginate and Its Role in Protecting Nitrogenase. Applied and Environmental Microbiology, 66(9), 4037–4044. https://doi.org/10.1128/aem.66.9.4037-4044.2000.
Sabra, W., Zeng, A.-P., Sabry, S. A., Omar, S. S., & Deckwer, W.-D. (1999). Effect of phosphate and oxygen concentrations on alginate production and stoichiometry of metabolism of Azotobacter vinelandii under microaerobic conditions. Applied Microbiology and Biotechnology, 52(6), 773–780. https://doi.org/10.1007/s002530051590.

Dr. Wael Sabra

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